I personally think each of the challenges are well thought out!
Favourites: Badder Bosses and Swarm Intelligence. These imho add a nice layer to the game.
Least favourite: Into the darkness, it annoys me getting sniped from a ranged enemy without seeing anything.
Special shout-out to pharmacopoeia and faith is my armour. I cannot finish the game with these on - anyone got any tips?
I can honestly say that I’ve not yet tried any challenges. But you’ve got me interested now, thanks for that!